Figure 6
From: CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
Memory deficits in Caps1 cKO adult mice. (a) Changes in the freezing ratio during the CFC conditioning and LTM retrieval tests. The schematic timeline is depicted above the line graph. ***P < 0.001, repeated two-way ANOVA (Genotype; F(1, 9) = 5.09, P = 0.505 during shock in conditioning phase (1–3 min); F(1, 9) = 1.14, P = 0.313 during baseline in conditioning phase (4–6 min); F(1, 9) = 23.87, P < 0.001 during retrieval test). (b) Mean freezing ratio during the LTM retrieval test. Control, n = 6 animals; Caps1 cKO, n = 5 animals. ***P < 0.001, Student’s t-test. (c) Changes in the freezing ratio during AFC conditioning and LTM retrieval testing. The schematic timeline is depicted above the line graph. No significant change between the two groups occurred, repeated two-way ANOVA (Genotype; F(1, 10) = 2.85, P = 0.122 at baseline in the conditioning phase (0.5–3 min); F(1, 10) = 0.01, P = 0.912 during tone with shock in conditioning phase (3.5–7.5 min); F(1, 10) = 0.91, P = 0.895 at baseline in retrieval test (1–2 min); F(1, 10) = 0.02, P = 0.362 during tone in retrieval test (3–4 min)). (d) Mean freezing ratio during tone representation in the AFC-LTM test. Control, n = 7 animals; Caps1 cKO, n = 5 animals. P = 0.895, Student’s t-test. (e) Changes in the freezing ratio during CFC conditioning and STM retrieval testing. The schematic timeline is depicted above the line graph. ***P < 0.001, repeated two-way ANOVA (Genotype; F(1, 28) = 1.08, P = 0.307 during baseline in conditioning phase; F(1, 28) = 0.01, P = 0.935 during shock in conditioning phase; F(1, 28) = 18.08, P < 0.001 during retrieval test). (f) Mean freezing ratio during the CFC-STM retrieval test. Control: n = 19 animals; Caps1 cKO: n = 11 animals. ***P < 0.001, Student’s t-test.
