Figure 3

Reduced potential of BSRC memory T-cells to exert effector function. (A) Exemplary gating strategy of CD45RO⁺ memory T-cells and exemplary gating strategy of different cytokines after 6 h polyclonal activation in CD4⁺ (A) and CD8⁺ (C) T cells in control probands (upper row) and patients (lower row) respectively. (B,D) Analysis of IFN-γ, TNF-α, IL-2, IL-4, IL-17, and IL-22-producing CD45RO⁺ T-cell fractions in controls and BSCR patients. Lines indicate median. Mann Whitney U test was used for statistical analysis p < 0.05*. BSRC birdshot retinochoroiditis, IFN-γ interferon gamma, IL interleukin, TNF-α tumor necrosis factor alpha.