Table 2 The association of the UCP2 gene and dietary factors with CHDs in univariate analyses.

From: Association and interaction effect of UCP2 gene polymorphisms and dietary factors with congenital heart diseases in Chinese Han population

SNP

Controls

CHDs

cOR(95%CI)

P

Dietary factors

Controls

CHDs

cOR(95%CI)

P

N(%)

N(%)

N(%)

N(%)

rs659366

Pickled vegetables

    

Additive model

    

Never

330(65.5)

253(54.5)

1.00

 

CC

252(50.0)

158(34.0)

1

 

Excessive

174(34.5)

211(45.5)

1.58(1.22–2.05)

0.001

TC

192(38.1)

210(45.3)

1.74(1.32–2.31)

 < 0.001

Smoked foods

    

TT

60(11.9)

96(20.7)

2.55(1.75–3.73)

 < 0.001

Never

276(54.8)

190(40.9)

1.00

 

Recessive model

    

Excessive

228 (45.2)

274(59.1)

1.75(1.35–2.25)

 < 0.001

CC + TC

444(88.1)

368(79.3)

1

 

Barbecued foods

    

TT

60(11.9)

96(20.7)

1.93(1.36–2.74)

 < 0.001

Never

376(74.6)

293(63.1)

1.00

 

Dominant model

    

Excessive

128(25.4)

171(36.9)

1.71(1.30–2.26)

 < 0.001

CC

252(50.0)

158(34.1)

1

 

Fried foods

    

TC + TT

252(50.0)

306(65.9)

1.94(1.49–2.51)

 < 0.001

Never

306(60.7)

235(50.6)

1.00

 

rs660339

Excessive

198(39.3)

229(49.4)

1.51(1.17–1.94)

0.002

Additive model

    

Fresh meat

    

GG

218(43.3)

136(29.3)

1

 

Never

22(4.4)

66(14.2)

1.00

 

GA

212(42.0)

216(46.6)

1.63(1.23–2.17)

0.001

Regular

482(95.6)

398(85.8)

0.26(0.17–0.45)

 < 0.001

AA

74(14.7)

112(24.1)

2.43(1.69–3.49)

 < 0.001

Fish and shrimp

    

Recessive model

    

Never

22(4.4)

98(21.1)

1.00

 

GG + GA

430(85.3)

352(75.9)

1

 

Regular

482(95.6)

366(78.9)

0.17(0.11–0.28)

 < 0.001

AA

74(14.7)

112(24.1)

1.85(1.34–2.56)

 < 0.001

Fresh eggs

    

Dominant model

    

Never

24(4.8)

60(12.9)

1.00

 

GG

218(43.3)

136(29.3)

1

 

Regular

480(95.2)

404(87.1)

0.34(0.21–0.55)

 < 0.001

GA + AA

286(56.7)

328(70.7)

1.84(1.41–2.40)

 < 0.001

Fresh vegetables

    

rs591758

Never

2(0.4)

2(0.4)

1.00

 

Additive model

    

Regular

502(99.6)

462(99.6)

0.92(0.13–6.56)

0.934

GG

180(35.7)

160(34.5)

1

 

Soy foods

    

GC

228(45.2)

212(45.7)

1.05(0.79–1.39)

0.756

Never

70(13.9)

144(31.0)

1.00

 

CC

96(19.1)

92(19.8)

1.08(0.76–1.54)

0.679

Regular

434(86.1)

320(69.0)

0.36(0.26–0.49)

 < 0.001

Recessive model

    

Milk products

    

GG + GC

408(81.0)

372(80.2)

1

 

Never

82(16.3)

241(51.9)

1.00

 

CC

96(19.0)

92(19.8)

1.05(0.76–1.45)

0.759

Regular

422(83.7)

223(48.1)

0.18(0.13–0.24)

 < 0.001

Dominant model

         

GG

180(35.7)

160(34.5)

1

      

GC + CC

324(64.3)

304(65.5)

1.06(0.81–1.38)

0.688

     
  1. CHDs congenital heart diseases; cOR crude odds ratio; CI confidence interval; SNPs single nucleotide polymorphisms;
  2. *Recessive model means homozygous variant vs heterozygous variant + homozygous wild-type.
  3. †Dominant model means homozygous variant + heterozygous variant vs homozygous wild-type.
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