Figure 3

Resistance training increases glucose-stimulated insulin secretion and improves beta-cell function. Glucose-stimulated insulin secretion (a) and total insulin content (b) of islets from CON (black bar, n = 10) and RET (red bar, n = 9–11). Real-time PCR assay of PDX1, Ins1 and Ins2 mRNA levels (c) in pancreatic islets of CON (black bar, n = 10) and RET (red bar, n = 6–10). Real-time PCR assay of BiP, XBP1, ATF4 and CHOP mRNA levels (d) in pancreatic islets of CON (black bar, n = 9–10) and RET (red bar, n = 8–10). The relative expression of mRNAs was determined after normalization with HPRT. Data are the mean ± SEM. *P ≤ 0.05 (Student’s t-test).