Table 6 The Robs/pre of PK parameters in healthy adults after oral administration of captopril.

From: Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases

PK parameters

Healthy

References

Observed

Predicted

Robs/pre

Oral administration

AUC0-∞ (ng/mL.h)

10 mg

100.51

115.68

0.87

18

25 mg

335.59

304.54

1.10

42

25 mg (Test)

348.67

318.55

1.09

41

25 mg (Reference)

334.03

317.78

1.05

41

50 mg

625.14

603.02

1.04

42

100 mg (Fasted)

1339.39

1233.91

1.09

23

100 mg (Fed)

782.07

1232.38

0.63

23

100 mg (Male)

789.28

1121.55

0.70

43

100 mg (Female)

781.54

1094.16

0.71

43

100 mg

1198.67

1191.55

1.01

19

100 mg (Geriatrics)

1415.87

1223.04

1.16

44

CL/F (L/h)

10 mg

99.48

86.45

1.15

18

25 mg

74.49

82.09

0.91

42

25 mg (Test)

71.70

78.48

0.91

41

25 mg (Reference)

74.84

78.67

0.95

41

50 mg

79.98

82.92

0.96

42

100 mg (Fasted)

74.66

81.04

0.92

23

100 mg (Fed)

127.86

81.14

1.58

23

100 mg (Male)

126.69

89.16

1.42

43

100 mg (Female)

127.95

91.39

1.40

43

100 mg

83.42

83.92

0.99

19

100 mg (Geriatrics)

70.62

81.76

0.86

44

Cmax (ng/mL)

10 mg

66.48

72.96

0.91

18

25 mg

138.09

192.29

0.72

42

25 mg (Test)

215.01

192.29

1.12

41

25 mg (Reference)

218.99

192.29

1.14

41

50 mg

231.26

384.61

0.60

42

100 mg (Fasted)

848.14

739.91

1.15

23

100 mg (Fed)

338.75

792.63

0.43

23

100 mg (Male)

480.65

750.21

0.64

43

100 mg (Female)

466.16

817.07

0.57

43

100 mg

768.17

747.28

1.03

19

100 mg (Geriatrics)

735.90

676.34

1.09

44

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