Figure 1
From: NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury
Increases in substance P immunoreactivity following diffuse TBI in rats. Immunohistochemistry (A) typically demonstrates the presence of substance P positive cortical neurons (arrowed) immediately below the impact site at 24 h after the final injury. While no significant increase was observed after a single mild TBI (smTBI), clear increases in substance P immunoreactivity were observed with increased intensity of the injury and with repeated exposure to the mild injury (rmTBI). Cell counts (B) and ELISA assay (C) confirm the immunohistochemistry findings. Mean ± SEM; n = 5–8/group; ** = p < 0.01, *** = p < 0.001 versus sham and smTBI.
