Figure 3
From: NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury
Changes in tau phosphorylation (serine 396, 50–60 kDa; arrow) and neurological outcome at 24 h and 28 days following blast TBI in mice, with and without administration of the NK1 antagonist EUC-001. Western blot images (A) and their quantitation (B) demonstrate a significant increase (p < 0.001) after injury versus shams, while treatment with the NK1 antagonist reduced the tau phosphorylation back to sham levels. Mean ± SEM; n = 6/group; *** = p < 0.001 versus no treatment. Improvements in neurological outcome were noted in rotarod performance (C), foot faults on the beam walk (D), and on the angleboard in the vertical (E) and horizontal position (F). Mean ± SEM; n = 6/group; * = p < 0.05, ** = p < 0.01, *** = p < 0.001 versus vehicle treated animals at the same time point.
