Table 4 Predictive ability of Cox regression models for progression-free and overall survival.
Modeling covariates | C-statistic (95% CI) | p versus null1 | p versus model without phenotype2 |
|---|---|---|---|
Progression-free survival | |||
Number of mutations | 0.50 (0.37–0.63) | 0.97 | |
Smoking status | 0.63 (0.47–0.78) | 0.09 | |
ECOG performance score | 0.69 (0.58–0.8) | < 0.005 | |
Radiomic phenotype | 0.63 (0.49–0.77) | 0.03 | |
Number of mutations, smoking status, and ECOG performance score | 0.73 (0.59–0.86) | < 0.005 | |
Radiomic phenotype, number of mutations, smoking status, and ECOG performance score | 0.77 (0.64–0.89) | < 0.005 | 0.01 |
Overall survival | |||
Number of mutations | 0.55 (0.31–0.8) | 0.46 | |
Smoking status | 0.69 (0.49–0.89) | 0.02 | |
ECOG performance score | 0.71 (0.55–0.88) | 0.02 | |
Radiomic phenotype | 0.62 (0.39–0.85) | 0.11 | |
Number of mutations, smoking status, and ECOG performance score | 0.80 (0.61–0.98) | 0.01 | |
Radiomic phenotype, number of mutations, smoking status, and ECOG performance score | 0.83 (0.67–1) | < 0.005 | 0.08 |
