Table 2 Canonical pathways identified in the heart by the Ingenuity Pathway Analysis based on the comparison of stressed with non-stressed untreated rats (4 rats/group), and those stressed and unstressed treated with ICI118,551 (4 rats/group).

From: Stress-induced differential gene expression in cardiac tissue

Untreated

ICI-treated

Heme biosynthesis II

Glucocorticoid receptor signaling

Eicosanoid signaling

IL17A signaling in fibroblasts

Mitotic roles of polo-like kinase

IL17 signaling

Cyclins and cell cycle regulation

Circadian rhythm signaling

S-adenosyl-L-methionine biosynthesis

Protein ubiquitination pathway

Cell cycle regulation by BTG family proteins

Acute phase response signaling

Heme biosynthesis from uroporphyrinogen III I

Apelin endothelial signaling pathway

Spermine and Spermidine degradation I

IL6 signaling

Tetrapyrrole biosynthesis II

PI3K signaling in B lymphocytes

Telomerase signaling

CD27 signaling in lymphocytes

CD40 signaling

IL10 signaling

cAMP mediated signaling

  1. Bold shading indicates prediction of activation and italics indicates prediction of inhibition.
  2. A list with additional information is available in Supplementary Table S4.
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