Figure 4

Dorsal and Ventral Hippocampal Volumes. (a) Representative 3D images of a sham-operated mouse, an MCAO-operated mouse with a non-infarcted hippocampus, and an MCAO-operated mouse with an infarcted hippocampus with automatic segmentation of the dorsal ipsilateral (purple), dorsal contralateral (aqua), ventral ipsilateral (green) and ventral contralateral (red) hippocampi at 12-weeks post-surgery. Volume changes of the dorsal (b) and ventral (c) ipsilateral and contralateral hippocampus in MCAO-operated mice with a non-infarcted hippocampus (gray diamonds) and with an infarcted hippocampus (white triangles) at each time point measured (n = 3–6). Random effect generalized least squares regression test. The effect sizes are presented as mean differences in volume (mm³) between the given time point and baseline with corresponding 95% confidence intervals (p < 0.05 when the error bars do not touch the dotted line at 0, and the further the deviation from this, the greater the difference).