Table 3 Age- and sex-specific cumulative risk of colorectal cancer in the general population and patients with Lynch syndrome.
From: Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
Sex | Age (years) | General population | MMR mutation carries† (95% CI) | MLH1 mutation carriers (95% CI) | MSH2 mutation carriers (95% CI) |
|---|---|---|---|---|---|
Male | 30 | 0.03 | 0.71 (0.28–1.79) | 0.75 (0.30–1.84) | 1.18 (0.38–3.64) |
40 | 0.16 | 3.59 (1.44–8.79) | 3.76 (1.53–9.07) | 5.86 (1.91–17.3) | |
50 | 0.53 | 11.6 (4.79–26.7) | 12.1 (5.07–27.4) | 18.4 (6.28–47.2) | |
60 | 1.56 | 30.4 (13.4–59.8) | 31.5 (14.2–60.9) | 45.0 (17.3–84.7) | |
70 | 3.82 | 58.7 (29.6–89.2) | 60.3 (31.1–89.9) | 76.7 (37.2–99.0) | |
Female | 30 | 0.02 | 0.31 (0.14–0.69) | 0.35 (0.15–0.83) | 0.65 (0.24–1.79) |
40 | 0.15 | 2.02 (0.91–4.47) | 2.29 (0.98–5.31) | 4.22 (1.55–11.2) | |
50 | 0.50 | 6.37 (2.90–13.7) | 7.19 (3.12–16.1) | 13.0 (4.92–31.8) | |
60 | 1.21 | 14.8 (6.90–30.1) | 16.6 (7.40–34.8) | 28.6 (11.5–60.5) | |
70 | 2.43 | 27.5 (13.4–51.3) | 30.6 (14.3–57.7) | 49.3 (21.9–84.5) |
