Figure 2 | Scientific Reports

Figure 2

From: Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models

Figure 2

Beige mice sustain a greater bacterial burden of M. avium 2-151 smt over time than C57BL/6. Bacterial burden in the (a) lung and (b) spleen assessed by CFU enumeration weekly post aerosol challenge with M. avium 2-151 smt in C57BL/6 (blue circles) and Beige mice (red squares), n = 4 mice per time point. (c–f) Percent of singlet cells from lung homogenate analyzed 24 h to 8 weeks post infection by flow cytometry for (c) neutrophils: Ly6G + Ly6C + , (d) mononuclear phagocytes: CD64 + CD11b + , (e) Lymphocytes: Ly6G− Ly6C− CD11c− CD11b− and (f) NK cells: CD64− NK1.1 + . Mean with SD represented, n = 4 mice per time point. *p < 0.05, unpaired t-test with Holm-Sidak correction for multiple comparisons.

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