Figure 4

Stochastic emergence of rough colony morphotype in vivo. Proportion of smooth (blue) and rough (orange) morphotypes from lung homogenates 1–8 weeks post infection with M. avium 2-151 smt in (a) C57BL/6 and (b) Beige mice. (c) Representative image of rough (orange arrow) and smooth (blue arrow) colony phenotypes from an ex vivo lung homogenate agar plate culture.