Figure 2 | Scientific Reports

Figure 2

From: Prostaglandin F2α agonists induced enhancement in collagen1 expression is involved in the pathogenesis of the deepening of upper eyelid sulcus

Figure 2

Changes in the sizes of three-dimension (3D) organoids of human orbital fibroblasts (HOFs) during the 3D cell culture in the absence or presence of different concentrations of Prostaglandin F2α analogues (PGF2α-ags). In the absence (closed squares) or presence of 1 (open circles), 100 (open squares) or 10,000 nmol/L (open triangles) of Bimatoprost acid (BIM-A), PGF2α or latanoprost acid (LAT-A), changes in the mean sizes of the HOFs organoids of DIF during the 12-day period of the culture were plotted (panel A), and their mean sizes at Day 12 were compared among the different concentrations (panel B). All experiments were performed in triplicate using fresh preparations consisting of 16 organoids each. Data are presented as the arithmetic mean ± standard error of the mean (SEM). *P < 0.05, ***P < 0.005 (ANOVA followed by a Tukey’s multiple comparison test).

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