Figure 3 | Scientific Reports

Figure 3

From: Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

Figure 3

Structural determination of newly isolated hemiacetal-less rapamycin derivatives. (a) Structures of rapamycin and compounds 2–4. The stereochemistry of the derivatives is deduced from that of rapamycin as well as the stereoselectivities of corresponding tailoring domains. (b) Selected 1H–1H DQF-COSY and HMBC correlations in 2–4. Bold lines and arrows show DQF-COSY and HMBC correlations, respectively.

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