Table 1 13C and 1H NMR spectroscopic data for 1 in acetone-d6 (150/600 MHz, respectively).

From: Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

No

δC

δH (multiplicity, J in Hz)

1

177.2

 

2

51.7

5.19 (m)

3

26.0

2.23 (d, 13.7), 1.53 (m)

4

20.5

1.67 (m), 1.37 (m)

5

25.1

1.59 (m), 1.41 (m)

6

43.9

3.59 (d, 12.7), 2.97 (dd, 3.0, 13.0)

8

166.6

 

9

50.5

3.86 (d, 16.3), 3.52 (d, 16.3)

10

203.6

 

11

50.1

2.67 (m)

12

65.4

4.04 (m)

13

41.0

1.70 (m), 1.65 (m)

14

85.0

3.82 (q, 7.4)

15

136.7

 

16

128.9

6.18 (d, 11)

17

127.2

6.51 (dd, 11.2, 13.9)

18

132.7

6.29 (dd, 10.7, 14.0)

19

131.1

6.24 (dd, 10.2, 14.3)

20

139.5

5.50 (dd, 9.4, 14.1)

21

36.0

2.29 (m)

22

39.5

1.52 (m), 1.16 (m)

23

40.9

2.73 (m)

24

211.3

 

25

85.2

3.96 (d, 6.4)

26

77.4

4.10 (d, 5.6)

27

137.6

 

28

126.7

5.21 (d, 4.4)

29

46.0

3.53 (m)

30

207.7

 

31

40.4

2.92 (m), 2.64 (m)

32

74.0

5.20 (m)

33

32.9

1.97 (m)

34

39.5

1.12 (m), 1.06 (m)

35

33.1

1.42 (m)

36

35.5

2.07 (m), ovl; 0.65 (q, 11.6)

37

84.3

2.90 (m), ovl

38

73.9

3.28 (m)

39

32.3

1.86 (m), ovl; 1.27 (m)

40

31.0

1.72 (m), 0.92 (m)

41

9.7

1.68 (s)

42

21.3

1.02 (d, 6.5)

43

13.4

0.967 (d, 6.5)

44

12.2

1.85 (s)

45

14.8

0.974 (d, 6.5)

46

15.3

0.86 (d, 6.8)

47

55.0

3.12 (s)

48

57.1

3.23 (s)

49

56.2

3.35 (s)

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