Table 2 Breast cancer risk assessment (case–control) of previously identified variant alleles.
SNV ID | Associated/neighboring genes | Minor allele | Overall BC risk (all samples) | SIR African Americans | SIR Ghanaians | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Models without covariates | Models with covariates* | Models with covariates** | Models with covariates** | |||||||||||
N | OR (95% CI) | P value | N | OR (95% CI) | P value | N | OR (95% CI) | P value | N | OR (95% CI) | P value | |||
rs13000023 | TNP1, DIRC3 | A | 420 | 1.048 (0.756, 1.449) | 0.775 | 271 | 1.061 (0.601, 1.874) | 0.838 | 104 | – | – | 75 | 0.909 (0.466, 1.770) | 0.780 |
rs2363956 | ANKLE1 | G | 415 | 0.847 (0.629, 1.140) | 0.273 | 274 | 1.272 (0.718, 2.254) | 0.409 | 103 | 0.916 (0.135, 6.197) | 0.928 | 76 | 1.409 (0.688, 2.890) | 0.349 |
rs2981578 | FGFR2 | T | 416 | 1.508 (1.111, 2.047) | 0.008 | 267 | 1.036 (0.611, 1.759) | 0.895 | 99 | – | – | 78 | 0.891 (0.481, 1.650) | 0.713 |
rs2981579 | FGFR2 | G | 418 | 1.246 (0.928, 1.675) | 0.144 | 269 | 1.899 (1.063, 3.393) | 0.030 | 99 | – | – | 77 | 1.792 (0.905, 3.545) | 0.095 |
rs3112572 | CASC16, LOC643714 | A | 385 | 1.007 (0.691, 1.467) | 0.972 | 246 | 2.410 (1.086, 5.347) | 0.031 | 96 | – | – | 65 | 2.088 (0.948, 4.597) | 0.068 |
rs3745185 | BABAM1 | A | 409 | 0.666 (0.492, 0.901) | 0.008 | 265 | 0.618 (0.341, 1.119) | 0.112 | 99 | 0.787 (0.104, 5.947) | 0.816 | 77 | 0.590 (0.272, 1.280) | 0.182 |
rs4245739 | MDM4 | C | 409 | 1.193 (0.860, 1.654) | 0.291 | 264 | 0.995 (0.569, 1.740) | 0.986 | 97 | 0.008 (0.000, 20.16) | 0.228 | 75 | 0.838 (0.427, 1.644) | 0.607 |
rs4849887 | LOC84934, GLI2 | C | 403 | 1.654 (1.154, 2.371) | 0.006 | 257 | 0.790 (0.351, 1.776) | 0.568 | 100 | 0.399 (0.013, 12.43) | 0.601 | 69 | 0.754 (0.274, 2.073) | 0.584 |
rs609275 | MYEOV, CCND1 | T | 396 | 1.129 (0.822, 1.552) | 0.453 | 253 | 1.121 (0.532, 2.361) | 0.764 | 98 | 0.224 (0.014, 3.646) | 0.293 | 67 | 0.920 (0.389, 2.176) | 0.849 |
