Table 3 TNBC-specific risk assessment (case-series) of previously identified variant alleles.

From: Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort

SNV ID

Associated/neighboring genes

Minor allele

Overall TNBC risk (all samples)

SIR African Americans

SIR Ghanaians

Models without covariates

Models with covariates*

Models with covariates**

Models with covariates***

N

OR (95% CI)

P value

N

OR (95% CI)

P value

N

OR (95% CI)

P value

N

OR (95% CI)

P value

rs13000023

TNP1, DIRC3

A

197

0.682 (0.410, 1.133)

0.139

190

0.781 (0.439, 1.387)

0.399

96

1.109 (0.538, 2.286)

0.780

6

–

–

rs2363956

ANKLE1

G

201

0.593 (0.389, 0.903)

0.015

194

0.542 (0.332, 0.883)

0.014

95

0.420 (0.230, 0.769)

0.005

8

1.471 (0.057, 38.26)

0.816

rs2981578

FGFR2

T

190

0.667 (0.435, 1.022)

0.063

183

1.248 (0.718, 2.169)

0.432

92

1.304 (0.656, 2.590)

0.449

6

17.55 (0.010, 29,760)

0.450

rs2981579

FGFR2

G

193

0.790 (0.515, 1.212)

0.280

186

0.978 (0.599, 1.597)

0.930

92

0.942 (0.530, 1.672)

0.838

6

6.261E−08 (0, –)

0.993

rs3112572

CASC16, LOC643714

A

181

1.546 (0.880, 2.716)

0.130

174

0.748 (0.394, 1.421)

0.375

89

0.714 (0.367, 1.390)

0.322

5

6.976E−49 (0, –)

0.976

rs3745185

BABAM1

A

189

0.503 (0.306, 0.843)

0.009

182

0.682 (0.386, 1.203)

0.180

92

0.584 (0.288, 1.182)

0.135

6

3.304 (0.090, 120.90)

0.515

rs4245739

MDM4

C

190

0.906 (0.571, 1.438)

0.675

183

1.130 (0.658, 1.941)

0.657

90

0.861 (0.440, 1.685)

0.663

6

0.356 (0.004, 34.530)

0.658

rs4849887

LOC84934, GLI2

C

189

0.414 (0.232, 0.738)

0.003

182

0.666 (0.338, 1.313)

0.240

93

0.542 (0.241, 1.221)

0.140

6

0.676 (0.0470, 9.710)

0.773

rs609275

MYEOV, CCND1

T

187

2.479 (1.593, 3.857)

 < 0.001

180

1.245 (0.717, 2.163)

0.437

91

1.121 (0.610, 2.061)

0.714

6

14.23 (0.0261, 7750)

0.409

  1. Significant alleles (p value < 0.05) are given in bold and italic
  2. *Overall analysis models with covariates adjusts for age and SIR.
  3. **SIR AA models with covariates adjusts for age and West African ancestry.
  4. ***SIR Ghanaian models with covariates adjusts for age.
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