Figure 1 | Scientific Reports

Figure 1

From: In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

Figure 1

Gene expression differences between sample sites: (a) Schematic of disease progression in DR (NPDR: Non-Proliferative Diabetic Retinopathy, PDR: Proliferative Diabetic Retinopathy, DME: Diabetic Macular Edema). From left to right the Diabetic Retinopathy Severity Score (DRSS) increases. (b) Principal component analysis (PCA) scores of combined and processed mRNA and miRNA expression values for all samples. (c) PCA scores of macula samples only. (d) PCA scores of periphery samples only. In all cases, PCA was applied to the top 100 most variable features in each sample group (all, macula, periphery). Cumulative R2-values for two principal components are shown in the upper right corner.

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