Figure 4
Molecular pathways associated with different disease stages of DR: (a) Barplot showing BH-adjusted p values of KEGG 2016 pathway enrichment analysis for each the four identified groups of disease-associated transcripts (left panel, Oxidative phosphorylation BH adjusted p value = 1.15e−07). Only pathways with BH-adjusted p value < 0.05 are shown. Middle and right panel indicate the direction of change in NPDR/PDR + DME samples vs healthy control for each of the significantly changing transcripts included in a given pathway (Middle panel: Macula; Right panel: Periphery). (b) Distribution of fold-changes for each sample group vs healthy controls for transcripts associated with the Neuroactive ligand–receptor interaction pathway. Black dots indicate fold-changes of individual genes in the Neuroactive ligand–receptor interaction pathway. As example, we specifically plot Glucagon Receptor (GCGR). The background distribution shows fold-changes [log2] of all transcripts not included in the pathway.
