Table 1 Effect of intervention and model on serum creatinine in mice with AKI.

From: Therapeutic effects of micro-RNAs in preclinical studies of acute kidney injury: a systematic review and meta-analysis

Study⁺	miRNA	AKI model	Comparator SCr (µM)	SD	n	Intervention SCr (µM)	SD	n	Mean difference	95% CI ( +)	95% CI (−)
Mimic
Wang et al., (2020)³*	miR-218-5p	IRI	28.1	6.4	9	18.4	5.5	9	− 9.7	− 4.2	− 15.2
Zhao et al., (2020)⁷*	miR-27a-3p	IRI	125.1	34.8	3	162.7	60.4	3	37.6	116.4	− 41.3
Chen et al., (2019)⁸*	miR-424	IRI	217.5	24.5	NS	128.3	17.0	NS	− 89.2	− 65.4	− 113.0
Liu et al., (2019)¹¹*	miR-377	IRI	209.2	44.0	8	229.8	99.8	8	20.6	96.2	− 55.0
Zhu et al., (2019)²¹*	miR-204-5p	IRI	62.3	8.6	6	28.6	4.5	6	− 33.7	− 25.9	− 41.5
Song et al., (2018)²⁹*	multiple including miR-17–92 cluster	IRI	51.1	3.3	5	37.6	4.4	5	− 13.5	− 8.7	− 18.3
Wei et al., (2018)³⁰*	miR-668	IRI	203.4	53.6	6	127.6	50.2	7	− 75.8	− 19.3	− 132.3
Hao et al., (2017)³⁷*	miR-17-5p	IRI	209.0	31.6	5	130.2	24.0	5	− 78.8	− 44.0	− 113.6
Huang et al., (2018)³⁸*	miR-146	IRI	59.0	8.2	6	40.8	2.0	6	− 18.2	− 11.4	− 25.0
Chen et al., (2016a)⁴⁹*	miR-16	IRI	82.5	40.9	7	117.0	19.4	7	34.5	68.1	0.9
Liang et al., (2015)⁵⁸*	miR-26a	IRI	108.8	11.7	6	58.8	5.2	6	− 50.0	− 39.8	− 60.2
Lan et al., (2012)⁶⁷*	miR-494	IRI	65.9	32	7	135.5	82.5	7	69.6	135.2	4.0
	Total		118.5	29.8	74	101.3	45.0	75	− 17.2	− 5.0	− 29.5
Wei et al., (2020)⁴*	miR-21	Sepsis	48.4	19.9	4	77.9	17.4	4	29.5	55.4	3.6
Funahashi et al., (2019)⁹*	miR-146a	Sepsis	47.2	90.3	7	13.9	7.3	7	− 33.3	33.8	− 100.4
Li et al., (2018b)²⁵*	miR-124	Sepsis	152.5	19.4	20	45.2	10.4	20	− 107.3	− 97.7	− 116.9
	Total		82.7	54.5	31	45.7	12.4	31	− 37.0	− 17.3	− 56.7
Antagomir
Geng et al., (2020)²*	miR-21	IRI + IPC	67.6	23.3	6	145.72	36.6	6	78.1	112.8	43.4
Zhao et al., (2020)⁷*	miR-27a-3p	IRI	116.1	38.6	3	91.9	19.2	3	− 24.2	24.6	− 72.9
Li et al., (2019)¹⁰*	miR-23a	IRI	111.3	8.2	5	99.3	3.78	5	− 12.0	− 4.1	− 19.9
Liu et al., (2019)¹¹*	miR-377	IRI	209.2	44	8	156.5	60	8	− 52.7	− 1.1	− 104.3
Song et al., (2018a)²⁸*	miR-21	IRI	223.3	50.7	6	274.4	54.1	6	51.1	110.4	− 8.2
Wei et al., (2018)³⁰*	miR-668	IRI	178.2	37.8	6	239.9	28	7	61.7	97.5	25.9
Huang et al., (2018)³⁸*	miR-146	IRI	59.0	8.2	6	74.4	4	6	15.4	22.7	8.1
Jiao et al., (2017)⁴⁰*	miR-21	IRI + IPC	45.1	6.6	5	113.24	28.5	5	68.1	93.8	42.5
Xu et al., (2017a)⁴⁵*	miR-21	IRI + IPC	41	17.2	6	111.1	22.5	6	70.1	92.8	47.4
Xu et al., (2017b)⁴⁶*	miR-21	IRI + CoCl₂ PC	71.9	33.3	6	129.8	111.8	6	57.9	151.2	− 35.4
Chen et al., (2016a)⁴⁹*	miR-16	IRI	93.1	31.1	7	75.5	21.8	7	− 17.6	10.5	− 45.7
Dai et al., (2016)⁵¹*	miR-146a	IRI + LPS PC	54.2	10.3	6	158.6	27.8	6	104.4	128.1	80.7
Wei et al., (2016)⁵⁴*	miR-489	IRI	74.5	30.6	3 to 7	82	33.1	3 to 7	7.5	40.9	− 25.9
Bhatt et al., (2015)⁵⁵*	miR-687	IRI	227.9	8	4	104.3	35.6	4	− 123.6	− 87.8	− 159.4
Lorenzen et al., (2014)⁶³*	miR-24	IRI	225.7	12.7	20	121.7	21.9	20	− 104.0	− 92.9	− 115.1
Jia et al., (2013)⁶⁵*	miR-21	IRI + Xe PC	63.3	12.1	5	118.6	25.9	5	55.3	80.4	30.2
Lan et al., (2012)⁶⁷*	miR-494	IRI	86.9	19.2	5	55.4	21.5	5	− 31.5	− 6.2	− 56.8
Xu et al., (2012)⁶⁹*	mir-21	IRI	35.4	1.9	6	33.4	4.9	5	− 2.0	2.2	− 6.2
Xu et al., (2012)⁶⁹*	miR-21	IRI + IPC	18.6	2.8	6	26.9	3.8	5	8.3	12.2	4.4
	Total		105.4	25.5	123	116.5	52.4	122	11.1	21.4	0.8
Wei et al., (2020)⁴*	miR-21	Sepsis	50.1	6.5	4	31.1	18.5	4	− 19.0	0.2	− 38.2
Wang et al., (2017b)⁴³*	miR-107	Sepsis	81.4	5.7	5	48.7	6	5	− 32.7	− 25.4	− 40.0
Jia et al., (2017)³⁹*	miR-21	Sepsis + IPC	48.6	15.2	6 to 8	61.9	14	6 to 8	13.3	27.6	− 1.0
Jia et al., (2015)⁵⁷*	miR-21	Sepsis + Xe PC	39.4	9.7	6	53.8	17.8	6	14.4	30.6	− 1.8
	Total		54.9	10.0	23	48.9	14.9	23	− 6.0	1.3	− 13.3
Gene deletion
Wang et al., (2020)³*	miR-218-5p	IRI	22.7	5.7	8	208.8	86.2	9	186.0	246.1	126.0
Yan et al., (2020a)⁵*	miR-214	IRI	170.7	61.4	> 6	96.38	35.37	> 6	− 74.3	− 17.6	− 131.0
Ranganathan et al., (2015)⁶⁰*	miR-150	IRI	142.9	12	6	83.8	13.9	6	− 59.1	− 44.4	− 73.8
Wei et al., (2010)⁷⁰*	Multiple	IRI	197	72	4	69.1	28	4	− 127.9	− 52.2	− 203.6
	Total		133.3	47.8	24	114.5	49.1	25	− 18.8	8.3	− 46.0
Pan et al., (2019)¹³*	miR-21	Sepsis + IPC	44.9	10.3	4	141.4	9.7	4	96.5	110.4	82.6

AKI acute kidney injury, CI confidence interval, CoCl₂ PC cobalt chloride preconditioning, IPC ischemic preconditioning, IRI ischemia reperfusion injury, LPS PC lipopolysaccharide preconditioning, miRNA micro-RNA, n sample size, NS not specified, SCr serum creatinine, SD standard deviation, Xe PC xenon preconditioning.
*Study references are found in the Supplementary materials; + 5 studies in mice did not report creatinine and were excluded.

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Table 1 Effect of intervention and model on serum creatinine in mice with AKI.

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