Figure 6
From: Mexiletine-like cellular electrophysiological effects of GS967 in canine ventricular myocardium
Reversible effects of GS967 (A–C) and mexiletine (D–F) on beat-to-beat variability of APD in isolated myocytes. Superimposed sets of action potentials (A,D) and Poincaré plots (B,E) obtained in control, following exposure to 1 µM GS967 or 40 µM mexiletine, and after washout of drugs. (C) and (F) show the average effects on beat-to-beat variability (SV) and APD. Symbols and bars are mean ± SEM, small dots represent individual data, numbers in parentheses indicate the number of myocytes studied, asterisks denote significant differences between data of the pre-drug control and the GS967- or mexiletine-treated groups.
