Table 1 General information of childhood ALL patients with and without TLS.
From: Clinical characteristics of tumor lysis syndrome in childhood acute lymphoblastic leukemia
Without TLS 5458 (N%) | With TLS 79 (N%) | OR (95% CI)c | |
|---|---|---|---|
Age | |||
1 to 10 | 4689 (99.0) | 45 (1.0) | 1.00 |
≥ 10 | 689 (96.2) | 27 (3.8) | 2.2 (1.3–3.8) |
< 1 | 80 (92.0) | 7 (8.0) | 8.6 (3.0–22.2) |
Sex | |||
Female | 2232 (99.0) | 23 (1.0) | 1.00 |
Male | 3226 (98.3) | 56 (1.7) | 1.5 (0.9–2.5) |
WBCa (× 109/L) | |||
< 50 | 4351 (99.2) | 36 (0.8) | 1.00 |
≥ 50 | 1107 (96.3) | 43 (3.7) | 2.6 (1.6–4.5) |
Immunophenotype | |||
B | 4979 (99.2) | 42 (0.8) | 1.00 |
T | 479 (92.8) | 37 (7.2) | 4.7 (2.6–8.8) |
t(12;21)(ETV6-RUNX1) | |||
Present | 1067 (99.5) | 5 (0.5) | 1.00 |
Absent | 4391 (98.3) | 74 (1.7) | 0.9 (0.3–3.0) |
t(1;19)(TCF3-PBX1) | |||
Absent | 5185 (98.6) | 74 (1.4) | 1.00 |
Present | 273 (98.2) | 5 (1.8) | 0.6 (0.2–1.8) |
t(9;22)(BCR-ABL1) | |||
Absent | 5231 (98.6) | 76 (1.4) | 1.00 |
Present | 227 (98.7) | 3 (1.3) | 1.4 (0.5–6.0) |
KMT2A rearrangement | |||
Absent | 5285 (98.6) | 74 (1.4) | 1.00 |
Present | 173 (97.2) | 5 (2.8) | 1.3 (0.5–4.3) |
Chromosome | |||
Hyperdiploidy > 50 | 789 (99.4) | 5 (0.6) | 1.00 |
Othersb | 4669 (98.4) | 74 (1.6) | 0.9 (0.4–2.7) |
Risk | |||
LR | 2885 (99.6) | 11 (0.4) | 1.00 |
IR/HR | 2573 (97.4) | 68 (2.6) | 1.8 (0.7–4.4) |
