Figure 3
From: Dynamic miRNA changes during the process of epileptogenesis in an infantile and adult-onset model
The visualization of expression and clustering analyses of dysregulated miRNAs. Heatmap shows expression profiles for PCR-validated differentially expressed miRNAs in infantile and adult-onset epileptogenesis. Rows represent individual miRNAs, while columns correspond to samples (labelled R + randomly assigned sample number) from control (Ctrl; gold) and post-status epilepticus (SE; purple) rats. Each heatmap is split into blocks representing the periods between status epilepticus (SE) induction and sample collection: 24 h (dark gray), 7 days (gray), and 3 months (light gray). The visualized expression was normalized to a row-wise Z-score (subtracting the row mean from each cell, and then dividing the value by the standard deviation of the row). The Z-score color range was further scaled to − 3 to 3 for better visualization. The initial expression values were log10(expression + 0.1) transformed prior to Z-score normalization. The miRNA clustering dendrogram is shown on the left and revealed miRNAs with similar expression patterns across collection periods.
