Table 1 Descriptive statistics of patient characteristics for all pediatric aortic valve (AV) tissue samples featured in the study.

From: Collagen fiber regulation in human pediatric aortic valve development and disease

SKU

Age (years)

Pediatric age group

Gender

Race/ethnicity

BSA (m2)

Leaflet morphology

Aortic valve function

Normal

DB017

0.5

Infant

M

–

0.38

Trileaflet

Normal

DB051

0.66

Infant

M

C

0.34

Trileaflet

Normal

NDRI

2

Young child

M

L

0.63

Trileaflet

Not recorded

DB85

9

Child

F

C

0.95

Trileaflet

Normal

DB27

17

Adolescent

M

C

2.2

Trileaflet

Normal

Normal Averages

7.17 ± 7.5

 

75%M 25%F

75%C 25%L

1.03

  

pCAVS

DB106

0.04

Neonate

M

C

0.21

Bicuspid

Severe stenosis with AVI

DB43

0.15

Infant

M

C

0.24

Trileaflet

Moderate stenosis with AVI*

DB40

0.75

Infant

M

C

0.37

Bicuspid

Moderate stenosis

DB105

5

Young child

M

C

0.72

Bicuspid

Moderate stenosis with AVI

DB119

5

Young child

F

–

–

Bicuspid

Moderate stenosis with AVI

DB113

5

Young child

–

–

–

–

Trivial stenosis; severe AVI

DB18

6

Child

F

C

0.7

Bicuspid

Moderate stenosis with AVI

DB3

11

Child

F

C

1.5

Bicuspid

Moderate stenosis with AVI

DB117

12

Adolescent

M

–

 

Bicuspid

Moderate stenosis with AVI

DB41

14

Adolescent

M

C

1.6

Bicuspid

Moderate stenosis with AVI

DB16

17

Adolescent

M

C

2.1

Bicuspid

Moderate stenosis with AVI

pCAVS Averages

6.90 ± 5.8

 

70%M 30%F

100%C

0.93

  

AVI

DB114

0.17

Infant

F

–

–

Trileaflet

Trivial AVI

DB007

0.58

Infant

–

–

–

Trileaflet

Mild nAVI

DB108

10

Child

F

C

1.3

Trileaflet

Thickened with AVI

DB83

10

Child

F

AA

1.4

Trileaflet

Trivial AVI

DB032

16

Adolescent

–

–

–

Trileaflet

Mild nAVI

AVI Averages

7.35 ± 6.8

 

–

–

1.35

  
  1. Normal AVs are from cardiac transplant patients where normal AV function is define by 2D echocardiogram. 2D Echocardiogram mean gradients define pre-operative AV function where a normal gradient is defined as < 5 mmHg, mild stenosis as 5–25 mmHg, moderate stenosis as 25–50 mmHg, and severe stenosis as > 50 mmHg. BSA: body surface area; C: Caucasian; L: Latino; AA: African American; MD: Myxomatous Degeneration. DB43 was included in pCAVS due to stenosis, but main diagnosis was Hypertrophic Cardiomyopathy. Pediatric Age Groups are defined by National Institute of Child and Human Development: Neonate (0–30d), Infant (1 mo–2yrs), young Child (2–6 yrs), Child (6–12 yrs), Adolescent (12–18 yrs). Experiment information can be seen in Supplemental Table S5.
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