Figure 5
The network shows the relationship among drug candidates, signature proteins and the five viruses. The concentric circles show the network of diseases (purple circles), proteins (red and yellow circles) and drugs (green circles). The numbers of extended signature proteins (yellow) for DENV, ZIKV, WNV, CHIV and JEV are 262, 351, 352, 289 and 99, respectively. The degrees of the proteins calculated from the PPI network in the HPRD are divided into 0 to 10, 10 to 20, 20 to 30, 30 to 40, 40 to 50 and 50 or greater. The circularly distributed proteins with smaller radii indicate higher degrees. The numbers of common (red) and extended (yellow) proteins counting from the outer circle inwards are 32, 34, 40, 46, 48 and 57 for common proteins and 47, 54, 71, 94, 116 and 190 for extended proteins. The purple edge shows the connection between the disease and common proteins. The green edge shows the signature protein-drug candidate interactions.
