Figure 8 | Scientific Reports

Figure 8

From: Morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy for superior image interpretation and clinical diagnosis

Figure 8

To determine ‘pure’ component spectra, which best represent the three major tissue components, i.e. epithelium tissue, collage, and esterified lipids, a combination of VCA and MCR-ALS was used. Ten endmember spectra extracted from the dataset, using vertex component analysis are displayed, (a) Three components from the VCA-endmembers were selected as the initial guess for MCR, i.e. Nr. 1 (collagen), Nr. 3 (esterified lipids), and Nr. 8 (epithelium tissue) and the resulting pure component spectra are shown, (b) The mean spectrum of the data set and the standard deviation of the residuals is plotted, (c) To better visualize the results the maps on the distribution of the three components are presented as RGB-maps for the several biopsies, (d).

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