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Figure 1

From: African Americans and European Americans exhibit distinct gene expression patterns across tissues and tumors associated with immunologic functions and environmental exposures

Figure 1

Gene Set Enrichment Analysis (GSEA) enrichment of KEGG pathways in African Americans compared to European Americans in pooled GTEx data. GSEA comprehensively analyses data for expression of all genes, rather than only the DE genes. (A) The most common pathways enriched among upregulated genes in African Americans for tissue-types in GTEx. See Additional File 3 for complete list of enriched pathways in 25 tissue-types. CK-CK, cytokine-cytokine receptor interaction; glutathione-oxidative metabolism includes (oxidative) metabolism of xenobiotics. The full enrichment analysis for each tissue-type is shown in Supplementary Table S57–S59. (B) The five most highly enriched pathways among upregulated genes of pooled samples from all tissue-types in GTEx are: Tol-like receptor signaling; chemokine signaling; primary immunodeficiency; viral protein interaction with cytokine and cytokine receptor; metabolism of xenobiotics by cytochrome P450.

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