Figure 3 | Scientific Reports

Figure 3

From: African Americans and European Americans exhibit distinct gene expression patterns across tissues and tumors associated with immunologic functions and environmental exposures

Figure 3

Differential expression of the HAP40 genes F8A1 and F8A2 in African Americans and European Americans across multiple tissue-types. HAP40 is a key molecular component of Huntington’s Disease, and shifts endosomal trafficking from the microtubules to actin fibers30. (A) F8A1 expression is upregulated in European Americans. (B) F8A2 expression is upregulated in African Americans. Violin plots summarize expression over each sample across the two populations. AA African American, EA European American. Horizontal lines represent mean log expression. Green asterisk, MW test for DE significant (BH corrected p value \(<0.05\)). Blue asterisk, Hartigans’ dip test. Expression distribution is influenced by differences in population sizes (significant p value \(<0.05\)). FC, fold change AA/EA. GTEx and TCGA violin plots represent the pooled samples from each project. DE were computed within MetaOmGraph (MOG)22, in MOG’s statistical analysis module; R scripts were executed interactively via MOG to generate the violin plots. (See Supplementary Fig. 2 for line plot comparison across individuals).

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