Table 2 Relative expression level of miRNAs in paired urine, serum, cervical scrapes, and tissue biopsies.

Sample	Pathology	miR-21-5p (FC ± SE)	P value	miR-145-5p (FC ± SE)	P value	miR-218-5p (FC ± SE)	P value	miR-34a-5p (FC ± SE)	P value	miR-155-5p (FC ± SE)	P value	miR-199a-5p (FC ± SE)	P value
Urine (n = 150) ^a	Pre-cancer (n = 50)	1.93 ± 0.9	< 0.0001	0.32 ± 0.1	< 0.0002	0.43 ± 0.1	< 0.0003	0.41 ± 0.1	< 0.0001	1.89 ± 0.2	< 0.0001	1.51 ± 0.3	< 0.0001
Urine (n = 150) ^a	Cancer (n = 50)	2.42 ± 0.1	< 0.0001	0.24 ± 0.5	< 0.0002	0.32 ± 0.4	< 0.0001	0.36 ± 0.2	< 0.0001	2.27 ± 0.20	< 0.0001	1.73 ± 0.1	< 0.0001
Serum (n = 150) ^a	Pre-cancer (n = 50)	2.10 ± 0.20	< 0.0001	0.15 ± 0.01	< 0.0001	0.34 ± 0.09	< 0.0001	0.27 ± 0.2	< 0.0001	1.72 ± 0.1	< 0.0001	1.81 ± 0.2	< 0.0001
Serum (n = 150) ^a	Cancer (n = 50)	2.72 ± 0.2	< 0.012	0.18 ± 0.01	< 0.0001	0.26 ± 0.03	< 0.008	0.21 ± 0.10	< 0.0001	2.16 ± 0.3	< 0.0001	1.92 ± 0.2	< 0.0001
Scrape (n = 90) ^b	Pre-cancer (n = 50)	2.3 ± 0.1	< 0.0001	0.13 ± 0.1	< 0.0001	0.28 ± 0.02	< 0.0001	0.23 ± 0.01	< 0.0001	1.94 ± 0.2	< 0.0001	2.02 ± 0.3	< 0.0001
Tissue biopsy (n = 70) ^c	Cancer (n = 40)	3.43 ± 0.3	< 0.0001	0.12 ± 0.2	< 0.0001	0.13 ± 0.2	< 0.0001	0.14 ± 0.2	< 0.0001	2.6 ± 0.4	< 0.0001	2.2 ± 0.3	< 0.0001

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