Table 2 Characteristics of the FoCus cohort.

From: Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure

 

Total

n = 387

Male

n = 105

Female

n = 282

Age (years)

53.4 ± 11.7 (21.0, 77.0)

56.3 ± 10.4 (30.0, 76.0) *

52.4 ± 12.1 (21.0, 77.0) *

Diabetes mellitus (%)

61 (15.8)

24 (22.9)

37 (13.1) *

Anthropometrics

Height (cm)

171.7 ± 9.0 (150.0, 207.0)

181.3 ± 7.3 (167.0, 207.0) *

168.1 ± 6.7 (150.0, 188.0) *

Weight (kg)

94.8 ± 37.0 (43.4, 203.8)

108.8 ± 38.5 (51.0, 198.7) *

89.6 ± 35.1 (43.4, 203.8) *

BMI (kg/m2)

32.1 ± 12.0 (14.3, 70.5)

33.0 ± 11.0 (16.1, 63.9)

31.7 ± 12.3 (14.3, 70.5)

Waist circumference (cm)

105.6 ± 28.6 (59.0, 150.0)

105.3 ± 28.7 (59.0, 150.0)

105.8 ± 28.7 (60.0, 150.0)

Blood pressure measures

Systolic blood pressure (mmHg)

129.0 ± 13.7 (95.0, 220.0)

128.9 ± 13.1 (100.0, 155.0)

129.0 ± 13.9 (95.0, 220.0)

Diastolic blood pressure (mmHg)

80.7 ± 7.5 (60.0, 110.0)

81.2 ± 7.2 (70.0, 95.0)

80.5 ± 7.6 (60.0, 110.0)

Measures of insulin resistance

Fasting glucose (mg/dL)

108.5 ± 39.6 (67.0, 387.0)

116.0 ± 39.1 (68.0, 329.0) *

105.6 ± 39.5 (67.0, 387.0) *

Fasting insulin (µIU/mL)1

10.4; 6.1–21.1 (0.2, 403.8)

12.5; 7.1–26.0 (0.4, 403.8)

9.9; 5.8–19.5 (0.2, 243.8)

HOMA-IR (ratio)1

2.5; 1.4–5.8 (0.1, 147.6)

3.2; 1.7–6.8 (0.3, 147.6) *

2.3; 1.3–5.2 (0.1, 99.3) *

Inflammation markers

IL-6 (pg/mL)1

3.6; 1.9–5.5 (1.5, 75.2)

4.0; 2.1–5.7 (1.5, 75.2)

3.5; 1.9–5.3 (1.5, 30.8)

CRP (mg/L)1

2.1; 0.9–6.7 (0.9, 64.5)

1.9; 0.9–5.0 (0.9, 43.7)

2.2; 0.9–6.8 (0.9, 64.5)

Tryptophan (mg/dL)

1.63 ± 0.31 (0.80, 2.69)

1.73 ± 0.32 (0.80, 2.68) *

1.60 ± 0.30 (0.85, 2.69) *

Natriuretic peptides

NT-proBNP (pg/mL)1

8.5; 8.5–131.0 (0.0, 6,439.8)

8.5; 8.5–50.7 (0.0, 4,803.6) *

17.4; 8.5–153.1 (0.0, 6,439.8) *

  1. Values are presented as mean ± SD for continuous variables or number (frequency) for categorical variables with minimum and maximum in parentheses. 1Skewed values are expressed as medians with interquartile ranges and with minimum and maximum in parentheses. Statistical significance between males and females was determined with unpaired t test for normally distributed data, with Wilcoxon test for skewed data, and with χ2 test for categorical data. An asterisk (*) denotes significant differences between both groups (p < 0.05).
  2. BMI, body mass index; CRP, C-reactive protein; HOMA-IR, homeostatic model assessment of insulin resistance; IL-6, interleukin 6; NT-proBNP, N-terminal pro brain natriuretic peptide.
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