Figure 5 | Scientific Reports

Figure 5

From: Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy

Figure 5

Regulatory network of selected hypermethylated genes associated with risk factors in head and neck cancer. Genes regulated by methylation from independent published studies in head and neck cancer (such as GAB1, TGFB, and JAK3) belongs to similar networks known to play a fundamental role in cancer progression. These methylated genes are targeted by the drugs, including TGF-beta receptor type II (Lerdelimumab, Suramin, and Interferon beta), GAB1-RA (Primidone, Flumazenil, Oxazepam, Flurazepam, Methylphenobarbital, Clorazepate, Ganaxolone, Clomethiazole, Zaleplon, Ocinaplon, Methyprylon, Indiplon, Zolpidem, Pentobarbital and Secobarbital), JAK 3 (Tofacitinib). Graphs were extracted from Metacore, Thompson Reuters (https://portal.genego.com).

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