Figure 11
From: The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone
LLRE complex composition at the E2F1 binding site of the BRCA1 promoter. BRCA1 is specifically downregulated by dex only in AT 648 hT cells, and likely transcribed by E2F1. At the E2F1 consensus binding site the amounts of (A) Lamin A/C, (B) LAP2α, (C) pRB and (D) E2F1 are reported for all samples. In this context, the only reasonable explanation is the inhibitory repressor effect of Lamin A/C on the LLRE complex, while all other factors remain unchanged.
