Figure 12
From: The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone
Condensing illustration of the effects of dex on Lamin A/C and downstream partners. In AT cells, globally dex promoted the release of Lamin A/C from higher level organized chromatin structures, as revealed by EDD peaks, probably by phosphorylation and LAP2α interaction. Locally, dex altered the LLRE composition determining a different outcome in gene regulation. The LLRE component colors on gene promoters represent increased (red), decreased (green) or unaltered (yellow) amounts of the indicated proteins on E2F1 binding site.
