Table 3 Associations of Fibrinogen, SII, and F-SII score with clinicopathological characteristics.

	Fibrinogen level (g/L)			SII			F-SII score
	< 3.37	≥ 3.37	P-values	< 372.8	≥ 372.8	P-values	0	1	2	P-values
Characteristics	n = 350	n = 258		n = 280	n = 328		n = 208	n = 214	n = 186
Age (years)			< 0.001			0.021				< 0.001
≥ 60	179	175		149	205		101	126	127
< 60	171	83		131	123		107	88	59
Sex			0.144			0.165				0.904
Male	273	188		205	256		159	160	142
Female	77	70		75	72		49	54	44
BMI (kg/m²)			0.065			0.124				0.114
≥ 24	102	58		82	78		64	56	40
< 24	248	200		198	250		144	158	146
ASA score			0.006			0.015				0.002
1	22	18		19	21		14	13	13
2	273	173		219	227		171	150	125
3	55	67		42	80		23	51	48
Tumor location			0.559			0.792				0.707
Upper	115	92		96	111		67	77	63
Middle	69	55		60	64		46	37	41
Lower	166	111		124	153		95	100	82
Tumor size (cm)			< 0.001			< 0.001				< 0.001
≥ 5	117	150		97	170		60	94	113
< 5	233	108		183	158		148	120	73
Histological grade			0.179			0.168				0.091
Well or moderately different	124	78		101	101		81	63	58
Poorly or not differentiated	226	180		179	227		127	151	128
Vascular invasion			0.281			0.55				0.586
Yes	35	33		29	39		20	24	24
No	315	225		251	289		188	190	162
Perineural invasion			0.236			0.063				0.033
Yes	118	99		89	128		60	87	70
No	232	159		191	200		148	127	116
Lymphatic invasion			0.707			0.611				0.605
Yes	36	29		28	37		19	26	20
No	314	229		252	291		189	188	166
TNM stage			< 0.001			< 0.001				< 0.001
I	89	26		78	37		68	31	16
II	80	61		60	81		42	56	43
III	181	171		142	210		98	127	127
Adjuvant chemotherapy			0.753			0.913				0.258
Yes	189	136		149	176		107	124	94
No	161	122		131	152		101	90	92

BMI Body Mass Index, ASA score American Society of Anesthesiologists score, SII Systemic immune-inflammation index, F-SII Fibrinogen and systemic immune-inflammation index.

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