Table 2 Metabolic profile changes after NST and 3 years after the initial treatment.

From: Comparison of metabolic changes after neoadjuvant endocrine and chemotherapy in ER-positive, HER2-negative breast cancer

Time

NCT group

NET group

Group p value**

Interaction between time and group*

Means

95% CI

Means

95% CI

BMI

Pre-NST

22.84

21.94

23.74

22.92

21.98

23.86

0.901

P < 0.001

Post-NST

23.87

23.06

24.68

22.85

22.01

23.70

0.088

3 years after treatment

22.82

22.04

23.61

23.20

22.38

24.01

0.513

Time p value***

 < 0.001

0.343

  

Total cholesterol

Pre-NST

181.44

172.96

189.91

186.34

177.58

195.11

0.428

P < 0.001

Post-NST

215.23

206.75

223.70

178.97

170.20

187.73

 < .001

3 years after treatment

176.15

167.58

184.72

179.38

170.56

188.19

0.605

Time p value

 < 0.001

0.177

  

Fasting Glc†

Pre-NST

95.36

92.55

98.26

97.28

94.29

100.36

0.365

P < 0.001

Post-NST

111.36

106.02

116.98

99.37

94.40

104.59

0.002

3 years after treatment

99.02

95.71

102.45

98.46

95.06

101.99

0.820

Time p value

 < 0.001

0.694

  
  1. BMI Body mass index, NST Neoadjuvant systemic treatment, NCT Neoadjuvant chemotherapy, NET Neoadjuvant endocrine therapy.
  2. *Indicates a significant difference between NCT and NET groups in changes over time.
  3. **Comparison between two groups by specific time.
  4. ***Significance of changes over time for each group.
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