Table 2 Significant canonical pathways among genes differentially expressed in irradiated old and young male mice as identified by Ingenuity Pathway Analysis.
From: Impact of aging on gene expression response to x-ray irradiation using mouse blood
YOUNG mice | OLD mice | ||||
|---|---|---|---|---|---|
Ingenuity canonical pathways | z-score | p value | Ingenuity canonical pathways | z-score | p value |
Upregulated | |||||
Integrin Signaling | 3.539 | 3.02 E−06 | Integrin Signaling | 4.529 | 9.77 E−06 |
Actin Cytoskeleton Signaling | 2.343 | 1.86 E−05 | Relaxin Signaling | 3.300 | 4.57 E−04 |
IL-8 Signaling | 3.363 | 1.07 E−04 | PPARα/RXRα Activation | 2.353 | 5.89 E−04 |
Apoptosis Signaling | 2.236 | 4.17 E−04 | Cardiac Hypertrophy Signaling | 3.000 | 1.86 E−03 |
P2Y Purigenic Receptor Signaling Pathway | 2.502 | 5.25 E−04 | eNOS Signaling | 2.985 | 2.19 E−03 |
Rac Signaling | 2.200 | 6.46 E−04 | P2Y Purigenic Receptor Signaling Pathway | 2.711 | 3.47 E−03 |
Regulation of Cellular Mechanics by Calpain Protease | 2.333 | 1.51 E−03 | Agrin Interactions at Neuromuscular Junction | 2.138 | 5.01 E−03 |
Cytotoxic T Lymphocyt E−mediated Apoptosis of Target Cells | 2.646 | 2.29 E−03 | GP6 Signaling Pathway | 2.858 | 7.08 E−03 |
Ephrin Receptor Signaling | 2.524 | 2.69 E−03 | Sperm Motility | 2.294 | 7.08 E−03 |
RhoA Signaling | 2.294 | 6.92 E−03 | Colorectal Cancer Metastasis Signaling | 2.263 | 1.26 E−02 |
Relaxin Signaling | 2.524 | 1.15 E−02 | Regulation of eIF4 and p70S6K Signaling | 2.121 | 1.41 E−02 |
Cardiac β-adrenergic Signaling | 2.000 | 1.62 E−02 | Role of NFAT in Cardiac Hypertrophy | 2.121 | 1.48 E−02 |
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes | 2.183 | 3.47 E−02 | Leptin Signaling in Obesity | 2.236 | 3.55 E−02 |
Agrin Interactions at Neuromuscular Junction | 2.309 | 4.79 E−02 | Signaling by Rho Family GTPases | 2.043 | 3.89 E−02 |
IL-8 Signaling | 3.272 | 4.27 E−02 | |||
Ephrin Receptor Signaling | 3.000 | 4.79 E−02 | |||
AMPK Signaling | 2.711 | 4.90 E−02 | |||
Downregulated | |||||
Calcium-induced T Lymphocyte Apoptosis | − 2.711 | 2.51 E−08 | EIF2 Signaling | − 3.138 | 5.13 E−04 |
iCOS-iCOSL Signaling in T Helper Cells | − 2.268 | 2.19 E−07 | Role of CHK Proteins in Cell Cycle Checkpoint Control | − 2.333 | 6.61 E−04 |
EIF2 Signaling | − 3.430 | 2.95 E−07 | B Cell Activating Factor Signaling | − 3.317 | 8.13 E−04 |
Role of CHK Proteins in Cell Cycle Checkpoint Control | − 2.111 | 4.90 E−04 | April Mediated Signaling | − 2.714 | 1.86 E−03 |
PKCα¸ Signaling in T Lymphocytes | − 2.502 | 5.01 E−04 | iCOS-iCOSL Signaling in T Helper Cells | − 2.236 | 2.24 E−03 |
B Cell Activating Factor Signaling | − 2.333 | 1.51 E−02 | PKCα¸ Signaling in T Lymphocytes | − 2.449 | 1.66 E−02 |
RhoGDI Signaling | − 2.132 | 2.00 E−02 | |||
LPS/IL-1 Mediated Inhibition of RXR Function | − 2.714 | 2.82 E−02 | |||
4-1BB Signaling in T Lymphocytes | − 2.449 | 4.68 E−02 | |||
CD27 Signaling in Lymphocytes | − 2.333 | 4.90 E−02 | |||
