Table 3 Ten most significant (ordered by p value) diseases and functions enriched among upregulated or downregulated genes in irradiated old and young male mice as identified by Ingenuity Pathway Analysis.

Upregulated

Cancer

4.425

2.90 E−33

Cancer

4.291

5.09 E−24

Development of vasculature

4.348

3.43 E−18

Cell movement

3.546

1.04 E−18

Angiogenesis

4.348

8.06 E−18

Cell movement of blood cells

3.519

1.31 E−10

Endocytosis

5.272

3.03 E−17

Adhesion of blood cells

3.564

5.08 E−07

Phagocytosis

6.210

1.77 E−15

Cell spreading

3.653

6.79 E−07

Phagocytosis of cells

5.691

6.41 E−15

Cell movement of leukocytes

3.542

2.72 E−06

Engulfment of cells

5.425

9.99 E−15

Cell death of osteosarcoma cells

4.596

7.82 E−06

Internalization of cells

5.053

1.28 E−13

Homing of cells

3.810

8.59 E−06

Phagocytosis of blood cells

4.331

2.10 E−11

Chemotaxis

3.778

2.61 E−05

Endocytosis by eukaryotic cells

4.882

6.37 E−11

Adhesion of immune cells

3.510

4.78 E−05

Downregulated

Quantity of lymphatic system cells

− 3.674

1.07 E−52

Quantity of IgG

− 3.802

9.33 E−12

Quantity of mononuclear leukocytes

− 3.402

1.93 E−49

Quantity of B lymphocytes

− 3.301

2.34 E−11

Quantity of lymphoid cells

− 3.418

4.70 E−49

Repair of DNA

− 3.519

7.05 E−08

Quantity of lymphocytes

− 3.522

8.02 E−49

Quantity of IgG1

− 3.473

7.74 E−08

Quantity of immunoglobulin

− 3.153

1.41 E−28

Checkpoint control

− 3.229

1.68 E−07

Quantity of B lymphocytes

− 4.263

3.89 E−27

Hemorrhagic disease

− 3.450

2.07 E−07

Quantity of lymphoid tissue

− 3.855

2.10 E−25

Development of B lymphocytes

− 2.995

2.09 E−06

Quantity of IgG

− 4.221

3.93 E−22

Stabilization of chromosomes

− 3.246

2.68 E−06

Quantity of IgG1

− 3.318

1.39 E−14

Excision repair

− 3.246

1.27 E−05

Antibody response

− 3.123

3.92 E−14

Bleeding

− 3.847

2.50 E−05