Table 4 Canonical pathways significantly over-represented among downregulated genes in control old versus young male mice under basal (no irradiation) conditions as assessed by Ingenuity Pathway Analysis.
From: Impact of aging on gene expression response to x-ray irradiation using mouse blood
Ingenuity canonical pathways | z-score | p value |
|---|---|---|
FGF signaling | − 2.837 | 3.72 E−04 |
Sperm motility | − 2.985 | 2.95 E−03 |
cAMP-mediated signaling | − 2.197 | 4.17 E−03 |
Wnt/Ca + pathway | − 2.673 | 4.79 E−03 |
GPCR-mediated nutrient sensing in enteroendocrine cells | − 2.837 | 5.62 E−03 |
Role of NFAT in cardiac hypertrophy | − 3.087 | 7.24 E−03 |
Synaptic long term depression | − 3.900 | 7.59 E−03 |
Neuropathic pain signaling in dorsal horn neurons | − 3.273 | 7.76 E−03 |
Neuroprotective role of THOP1 in Alzheimer's disease | − 3.153 | 1.15 E−02 |
Neurotrophin/TRK signaling | − 2.887 | 1.26 E−02 |
CREB signaling in neurons | − 3.545 | 1.29 E−02 |
Bladder Cancer Signaling | − 3.162 | 1.91 E−02 |
Actin Cytoskeleton Signaling | − 2.558 | 2.00 E−02 |
Basal Cell Carcinoma Signaling | − 2.530 | 3.47 E−02 |
GNRH Signaling | − 2.524 | 3.72 E−02 |
Endothelin-1 Signaling | − 2.268 | 3.89 E−02 |
ERK5 Signaling | − 2.714 | 3.89 E−02 |
Calcium Signaling | − 4.583 | 3.89E−02 |
