Figure 2
From: Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells
βPrlR+/− and Prlr+/− mice are glucose intolerant during pregnancy. (A) Glucose excursion during an intraperitoneal glucose tolerance test. (B) Integrated area under the curve (AUC) of glucose excursion during an 120-min IPGTT. (C) Random non-fasting blood glucose. (D) Glucose excursion during an intraperitoneal insulin tolerance. Blood glucose was expressed as a fraction of the blood glucose at time 0. “*” = p < 0.05, “**” = p < 0.01, and “****” = p < 0.001 in comparison to the wild type βPrlR+/+ mice by 2 way ANOVA (A, D) and 1 way ANOVA (B, C) with Tukey’s multiple comparisons tests. n = 3–19 mice per genotype.
