Figure 1 | Scientific Reports

Figure 1

From: A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure

Figure 1

Structural mapping of the PROSS-suggested amino acid substitutions. (a) Amino acid substitutions suggested by PROSS and grouped according to the physico-chemical properties of their side chains (hydrophobic: orange, polar: green, acidic: red, basic: blue). (b) The hERα-LBD homodimer (in light and dark gray) is shown in the canonical agonist-bound active conformation with helix 12 (H12) and coregulatory protein (CoR) binding highlighted in black and yellow, respectively. The agonist estradiol (EST) is depicted as a stick model. The positions of the substituted amino acids are marked with spheres using the same color code as in panel (a).

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