Figure 4
Forced exercise tolerance after TCDD exposure in mice from E0.5 through 12 months of age. The mice were run at 14 m/min for 60 min and the shock strength was set to 2.0 mA. Shocks were only counted when one of the following criteria were met: the mouse fell onto the shock bars, any part of the mouse touched the metal shock bars (exception: the mouse’s tail) or the mouse noticeably jumped from the shock. Failure was defined as the mouse can no longer run, the mouse does not respond to a shock or the mouse has reached a total of 50 shocks for the day. After failure, a mouse was immediately returned to its cage. Each dot represents an individual mouse. *p < 0.05 as measured by two-sided Mann–Whitney U test for a specific sex. Corn oil: n = 23 females, 16 males; TCDD: n = 14 females, 17 males. One male mouse was excluded due to inability to respond to shocks during acclimatization.
