Table 2 Concentrations of 26 compounds (ng/mL) in prenatal urine (not creatine adjusted) and blood samples, overall and by sex, n = 1,118.

From: Prenatal exposures to mixtures of endocrine disrupting chemicals and children’s weight trajectory up to age 5.5 in the SELMA study

Components of the EDC mixture

Overall

(n = 1,118)

Boys

(n = 584)

Girls

(n = 534)

P-value*

Matrix

Chemical Type

Parent compound

(if applicable)

Analyte

LOD/LOQa

% ≥ LOD

GM (GSD)

GM (GSD)

GM (GSD)

Urine

Phthalates

DEP

MEP

0.010

100

67.5 (2.9)

69.1 (2.8)

65.7 (3.1)

0.432

DBP

MBP

0.100

100

67.4 (2.2)

69.4 (2.2)

65.4 (2.2)

0.211

BBzP

MBzP

0.040

100

15.6 (2.9)

15.7 (2.8)

15.5 (3.0)

0.812

DEHP

ΣDEHPb

–

 

63.8 (2.4)

62.4 (2.3)

65.4 (2.5)

0.360

DINP

ΣDINPc

–

 

25.6 (3.0)

25.3 (3.0)

26.0 (3.0)

0.688

DiDP/DPHP

MHiDP

0.031

100

1.23 (2.8)

1.25 (2.7)

1.20 (2.8)

0.600

MCiNP

0.031

99.9

0.66 (2.4)

0.68 (2.4)

0.65 (2.5)

0.305

Plasticizer

DiNCH

MOiNCH

0.023

99.0

0.30 (4.0)

0.31 (4.1)

0.30 (4.0)

0.887

TTP

DPP

0.042

100

1.38 (2.6)

1.44 (2.6)

1.32 (2.5)

0.115

Antibacterial

 

Triclosan

0.100

92.4

1.34 (10.1)

1.36 (10.5)

1.31 (9.7)

0.762

Bisphenols

BPA

0.050

100

1.48 (2.4)

1.51 (2.3)

1.47 (2.4)

0.636

BPF

0.024

90.3

0.15 (5.2)

0.16 (5.1)

0.15 (5.3)

0.535

BPS

0.009

97.5

0.07 (2.9)

0.07 (2.8)

0.06 (3.0)

0.079

PAH

2OHPH

0.003

100

0.20 (2.3)

0.20 (2.3)

0.21 (2.3)

0.582

Pesticide

Chlorpyrifos

TCP

0.035

100

1.30 (2.5)

1.30 (2.5)

1.29 (2.6)

0.880

Pyrethroids

3-PBA

0.017

99.0

0.16 (2.8)

0.16 (2.7)

0.16 (2.8)

0.964

Serum

PFAS

 

PFOA

0.020

100

1.63 (1.7)

1.65 (1.7)

1.61 (1.8)

0.451

PFOS

0.060

100

5.49 (1.7)

5.56 (1.7)

5.42 (1.7)

0.406

PFNA

0.010

100

0.55 (1.7)

0.54 (1.7)

0.55 (1.7)

0.769

PFDA

0.020

100

0.26 (1.6)

0.26 (1.6)

0.26 (1.6)

0.897

PFUnDA

0.020

99.7

0.22 (1.9)

0.22 (1.9)

0.22 (1.8)

0.751

PFHxS

0.030

100

1.31 (1.8)

1.32 (1.8)

1.29 (1.8)

0.530

Plasma

Organo-chlorine pesticide

 

HCB

0.005

100

0.05 (1.4)

0.05 (1.4)

0.04 (1.4)

0.347

Trans-Nonachlor

0.005

77.5

0.01 (1.8)

0.01 (1.8)

0.01 (1.8)

0.989

DDT

ΣDDT/DDEd

–

 

0.20 (2.0)

0.21 (2.0)

0.20 (2.0)

0.166

PCB

 

ΣPCBe

–

 

0.36 (1.7)

0.37 (1.7)

0.36 (1.7)

0.500

  1. Abbreviations: GM = Geometric mean, GSD = Geometric standard deviation, LOD = limit of detection, LOQ = limit of quantification.
  2. Notes: Values < LOD retained the machine read value for urine and serum compounds, values < LOQ were substituted with LOQ/ 2 for plasma compounds. Further description of each analyte can be found in supplementary table S1.
  3. a LOD reported for all urine and serum compounds, LOQ reported for plasma compounds.
  4. b Molar sum of metabolites: mono-2-ethylhexyl, mono(2-ethyl-5-hydroxyhexyl), mono(2-ethyl-5-oxohexyl), and mono(2-ethyl-5-carboxypentyl) phthalates.
  5. c Molar sum of metabolites: mono(hydroxyisononyl), mono(oxoisononyl), and mono(carboxyisooctyl) phthalates.
  6. d Sum of DDT and its metabolite dichlorodiphenyldichloroethylene.
  7. e Sum of PCB congeners 74, 99, 118, 138, 153, 156, 170, 180, 183, 187.
  8. *P-value from Student t-test comparing metabolite concentrations on the log-scale by sex.
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