Table 3 Adjusted associations† from the WQS linear regression between prenatal EDC mixture and children´s growth characteristics, overall and by sex, n = 1,118.

From: Prenatal exposures to mixtures of endocrine disrupting chemicals and children’s weight trajectory up to age 5.5 in the SELMA study

 

Overall

(n = 1,118)

Boys‡

(n = 584)

Girls‡

(n = 534)

p-valueint

WQS index estimate (95% CI), p-value

WQS index estimate

(95% CI), p-value

WQS index estimate

(95% CI), p-value

Birthweight z-scores

− 0.11 (− 0.16, − 0.06), < 0.001

− 0.22 (− 0.37, − 0.07), 0.004

− 0.29 (− 0.44, − 0.14), < 0.001

0.526

Log10 of infant growth spurt rate (kg/months)

− 0.01 (− 0.03, − 0.004), 0.007

− 0.08 (− 0.11, − 0.05), < 0.001

− 0.05 (− 0.08, − 0.01), 0.005

0.103

Infant age at PGV (months)

0.15 (0.07, 0.24), < 0.001

− 0.04 (− 0.30, 0.22), 0.760

0.51 (0.26, 0.76), < 0.001

0.002

  1. Abbreviations: PGV = Peak growth velocity.
  2. †Adjusted for maternal age, BMI, education, smoking, parity, child’s sex and gestational age at birth. Models with birthweight z-scores as outcome were not adjusted for sex or gestational age. Stratified models were not adjusted for sex.
  3. ‡Results are derived from the stratified WQS model allowing for sex-specific weights and including the interaction term WQS*sex (p-valueint).
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