Table 4 Overall† and sex-specific weights‡ in the WQS linear regression analysis between prenatal EDC mixture analysis and children’s growth characteristics, overall and by sex, n = 1,118.

From: Prenatal exposures to mixtures of endocrine disrupting chemicals and children’s weight trajectory up to age 5.5 in the SELMA study

Components of the EDC mixture

Birthweight

z-scores

Infant growth spurt rate

Age at infant PGV

Matrix

Chemical Class

Parent compound

Analyte

Overall

Boys

Girls

Overall

Boys

Girls

Overall

Males

Females

(if applicable)

Weights (%)

Sex-specific weights (%)

Sex-specific weights (%)

Weights (%)

Sex-specific weights (%)

Sex-specific weights (%)

Weights (%)

Sex-specific weights (%)

Sex-specific weights (%)

Urine

Phthalates

DEP

MEP

2.9

3.2

3.3

4.3

3.4

6.6

7.5

3.3

10.9

DBP

MBP

6.1

1.1

9.0

0.1

3.4

0.1

1.0

1.6

0.4

BBzP

MBzP

2.0

1.9

7.0

2.0

3.8

0.7

4.7

4.0

3.1

DEHP

SumDEHP

2.0

0.8

3.5

3.1

1.6

1.9

1.0

2.2

< 0.1

DINP

SumDINP

 < 0.1

0.9

 < 0.1

3.5

3.0

9.6

1.3

0.9

0.8

DiDP/DPHP

MHiDP

0.6

1.1

 < 0.1

0.1

1.6

0.8

 < 0.1

3.1

0.7

MCiNP

9.0

4.6

9.9

0.2

7.4

4.3

1.6

8.0

7.9

Plasticizer

DiNCH

MOiNCH

3.8

10.7

0.6

7.5

4.1

9.5

10.9

5.3

7.8

TTP

DPP

0.9

2.6

0.4

15.7

8.9

6.7

5.7

3.3

2.0

Antibacterial

 

Triclosan

11.6

16.7

4.0

13.9

8.0

5.8

4.9

3.2

7.2

Bisphenols

 

BPA

0.8

1.9

0.9

1.2

3.3

1.7

11.4

3.9

9.1

BPF

0.1

2.0

0.2

5.5

3.5

3.5

2.5

2.9

1.3

BPS

7.7

9.2

2.4

0.5

3.8

0.6

2.9

3.3

2.1

PAH

 

2OHPH

10.4

7.8

7.4

2.1

4.1

4.8

1.7

8.1

6.5

Pesticide

Chlorpyrifos

TCP

0.6

5.9

 < 0.1

3.0

5.4

2.5

3.2

5.1

1.2

Pyrethroids

3-PBA

1.5

1.3

7.4

4.1

4.1

10.2

2.9

5.9

7.0

Serum

PFAS

 

PFOA

12.6

5.8

11.2

14.1

3.0

16.1

27.7

6.0

22.7

PFOS

2.1

1.1

5.5

0.3

2.6

0.7

 < 0.1

2.6

 < 0.1

PFNA

2.1

1.0

4.8

1.5

2.4

2.8

1.1

2.8

4.2

PFDA

6.2

4.9

5.7

5.2

1.5

6.5

0.1

6.1

0.3

PFUnDA

0.6

1.3

0.6

0.9

3.2

0.5

 < 0.1

3.2

0.4

PFHxS

1.0

1.7

1.0

 < 0.1

3.3

0.2

0.8

3.7

0.7

Plasma

Organo-chlorine pesticide

DDT

HCB

11.2

8.2

6.9

2.0

4.2

0.4

0.2

1.0

0.3

Trans-Nonachlor

1.0

1.7

1.0

 < 0.1

2.4

0.4

0.3

3.7

0.7

DDT/DDE

3.5

1.3

7.2

0.9

2.7

0.7

0.3

1.5

0.1

PCB

 

SumPCB

 < 0.1

1.6

0.2

8.4

5.4

2.5

6.4

5.4

2.7

  1. †Adjusted for maternal BMI, education, smoking, parity, child’s sex and gestational age at birth. Models with birthweight z-scores as outcome were not adjusted for sex or gestational age. Stratified models were not adjusted for sex.
  2. ‡ Weights represent the percentage attributable to each component of WQS index, and the sex-specific weights is that percentage calculated within each group (boys or girls). Chemicals with weights > 3.85% are marked in bold.
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