Figure 5
From: Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect
SPILLO-PBSS screenings for BTZ and CFZ. Plots resulting from the in silico screenings carried out for BTZ (Plot A) and CFZ (Plot B) on the available structural proteomes (26,141 protein 3D-structures retrieved from the RCSB PDB in August 2019, excluding 100% sequence identity redundancies) of Homo sapiens, Mus musculus, and Rattus norvegicus. Proteins are ranked in decreasing order according to their score. Tubulin (PDB code: 3RYC) was identified as a potential off-target for BTZ (4th position), but not for CFZ (835th position), which could account for the different neurotoxic profile of the two drugs (plots drawn using gnuplot15).
