Figure 6
From: Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect
Tubulin polymerization in DRG neurons. Representative images (A) and quantification graphs (B) of anti-tubulin immunoblotting in neurons, not treated (CTRL) or treated for 48 h with 2.8 nM BTZ and 3.2 nM CFZ. Graphs represent the percentage of polymerized tubulin (present in the pellet fraction P) compared to total tubulin (free tubulin, present in the substrate fraction S, added to polymerized tubulin). **p < 0.01 versus CTRL; °°p < 0.01 versus CFZ 3.2 nM.
