Figure 8
From: Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect
Tubulin polymerization and depolymerization in vitro with DMSO buffer. (A) In vitro cell-free tubulin polymerization in presence of 1 µM BTZ or 1 µM CFZ. (B) In vitro cell-free tubulin depolymerization in presence of 1 µM BTZ or 1 µM CFZ. (C) Phosphate quantification after tubulin polymerization assay. Graphs are represented as mean percentage ± SD compared to untreated CTRL (arbitrarily set to 100%). *p < 0.05; **p < 0.01 versus CTRL and versus CFZ.
