Figure 6

(A) Differences in average fitness due to mutation (fitness without mutation minus with mutation) for high and low entropy variants (P value = 2.3430e−04); see main text). The two distributions are clearly different with different medians (marked in thin lines) and spreads. (B) Spearman’s correlations between folding energy differences and fitness difference from wildtype vs. position in ORF1. (C) Spearman’s partial correlations between folding energy differences and fitness difference from wildtype given the number of mutations in the ORF vs. position in ORF1 (D) Fitness differences vs. folding energy differences of ORF1 mutated sequences compared to the wildtype in position 37 nucleotides from the start of ORF1 (ρ = 0.1971, P value = 0.0039).