Table 1 The most frequently selected features that entered the model and their correlation with the estimated fitness.

From: Computational based design and tracking of synthetic variants of Porcine circovirus reveal relations between silent genomic information and viral fitness

Name

Number of appearance (out of 20)

Spearman correlation

P value

Topological distance in the mRNA in position 865 ('mRNA_topo_dist_865')

10

0.6824

8.534e−70

Bend angle difference in the DNA in position 822 ('DNA_topo_dist_BendAngle_pos_822')

6

0.0435

0.3321

Mutation in position 785 ('mut_pos_785')

6

− 0.1435

0.0013

Folding energy difference in the DNA in position 779 ('DNA_FE_diff_779')

5

0.1675

0.0002

Mutation in position 831 ('mut_pos_831')

5

0.1240

0.0055

Mutation in position 849 ('mut_pos_849')

5

0.0325

0.4685

Folding energy difference in the DNA in position 737 ('DNA_FE_diff_737')

4

− 0.1593

0.0003

Topological distance in the mRNA in position 839 ('mRNA_topo_dist_839')

4

0.5965

1.64e−49

Mutation in position 813 ('mut_pos_813')

4

− 0.3942

4.89e−20